I have been in Colorado in late November for 28 of the last 38 years.
Weather in Colorado in November can be anywhere from mid-70s and beautiful sunny, to sub-freezing and a couple of feet of snow on the ground. Sometimes all in the same week.
In fact, usually, leading up to Thanksgiving, I often begin to entertain the idea of an outdoor picnic style Thanksgiving, like we used to have in Florida when I was a kid. But, the week before (sometimes just the day before) Thanksgiving, the weather always takes a dive, and we end up dining in. Thanksgiving weekend is not the time to be trekking across the western plains in a vehicle you are not familiar with, on roads you are not familiar with.
It can be done, and has been done, many times, but you need to understand what you could be getting yourself into, and you need to be prepared.