I don't consider myself an expert on this, but as I believe, the only difference between an E350 and an E450 is in the springs, suspension, and frame. ie. the E450 can carry more weight. The engine, tranny and rear axle are all exactly the same. So no difference in driving. BTW both the E350 & E450 use the 2 valve V10, 305HP, not the 3 valve V10, 362HP, used on the F53 chassis. Why? As best I can find it's a clearance issue, the 3 valve head is taller and simply won't fit into the E series chassis.