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No, I actually make sure it's full. In the summer heat I try and drain/refill every month or so, if it's cool/cold I'll go 2-3 months. Since it's likely you're using chlorinated water, it can sit for a long time.
If I am not going to use it for a few weeks I drain the fresh tank and the water heater so the anode rod does not continue to erode. Water is pretty cheap.
Unless it's been winterized, we leave water on board. We have used the motorhome for water, electricity and refrigeration numerous times for extended power outages. Twice so far this year.