What are you expecting to achieve? Better acceleration? Higher MPG? Less speed drop on grades?
Transcommand just alters the shift points for the tranny, meaning Banks thinks they have a better profile for power vs speed than Ford engineers. Any shift profile is a compromise, balancing the needs of various sets of operating environments. Always robbing Peter to pay Paul...
Headers improve exhaust flow but improved air intake has to be coupled with it. You can usually gain a few higher end horsepower that way. That may change the available Hp vs Rpm, creating some need for Transcommand to alter shift points to take advantage of it.
The downside is you spend a LOT of money to get very modest improvements in a V10. Back in the 80's and early-mid 90's, there was a decent amount to be gained. Not so much since about 1999 when more modern engineering and production capability vastly improved factory spec engines.
Banks has charts showing Hp and Torque improvements for various engines. As I recall, they can get some gains with the early V10's, but not so much with the later years.
I had a 1996 F53 with a 460 V8 and full Banks kit. However, I never drove the coach without the Banks mods, so don't have any way to subjectively evaluate what it did (or didn't) do. I know the mpg couldn't have been affected much - mine was about the same as everybody elses's.