Expanding on what Dazed said, you probably want to disconnect the rest of the RV from the batteries while equalizing, since the high voltage used can be hard on other 12v items, e.g. lights, control circuit boards, etc. They are designed primarily for 12v-14v operation and may be stressed by higher voltages. The 458 produces a whopping 16.3v during equalization.
Also make sure the 6v's are in pairs to make them effectively 12v batteries, so that equalization can work properly..
Your 458 manual describes equalization. Download it here if you don't have one.
http://www.xantrex.com/documents/Inverter-Chargers/Freedom-458/Freedom458%28445-0193-01-01_rev-2%29.pdf