Blueblood, I'm jumping in here a bit late. Let me work from the following quote.
For example, if she becomes lost -can she just have GPS take the co-ordinates and use as start point and lay out a way home. I am assuming the finsh point of my home can all ways be in the data.
I have a 2610 which I think would be better than the 2620 for your wife.
You could program the routes for her using your computer (rather than the 2610), although if she's a fighter she might well want to do that herself, and then with the handheld remote I think she'd find it straight forward to find the route she wants and to activate it.
But why, the 2610? Because I find programming routes on the unit itself to be very finicky; I prefer to do the route on the computer and upload it to the unit. I'm thinking that even your "fighting" wife might have trouble programming routes on the unit. You can program routes on the computer with the 2610, but I'm not sure (but don't think) that you can do that with the 2620.
As Bernie does, so do I: have stored the waypoint for my home and then, even from the unit, it is very easy to instruct the machine to route me home. Incidentally, when you get off the route, the program is really quite good at instructing you to get back on route. Mind you, the driver can often be more intelligent than the machine and so the machine's suggestions are at times "the long way round," but work.
Also, by programming on the computer you get a route going (which you save) and then by doing reverse, you get a route coming home (which you also save and upload both to the unit). As far as I know, you can't reverse the route when using the unit.
Ciao,
Doug