I had a 1995 WInnebago Vectra before the '07
Ford chassis, 460, 5.13 gears. Very choked back system, 195 degree thermostat had the temps up and the fan clutch engaged, robbing power and speed far more than neccessary. Many hills spent in 2nd gear, screaming along at 40-45mph. I decided to open up the intake to the air box, ran a K&N filter, half-shafted the dual intake throttle body, sharpened leading and trailing edges of the butterflies, msd ignition, balanced Mr. Gasket 180 degree high flow thermostat, a better balanced fan clutch, and opened up the exhaust with 3" ID pipe right from the y-pipe, a 3" ID resonator under the front to keep cab noise down, a Dynomax 3" ID in, 3 1/2" out, finishing up with a 3 1/2" mandrel-bent pipe in the factory location, and a 5" stainless Magnaflow tip for a clean look. Results, were beyond expectations. I pretty much gained a full gearon hills, where I'd lumber along in 2nd gear over 4,000rpm I was now in drive running 60mph. Passing wasn't a 2 mile long planned procedure anymore, I even passed my share of Duramax's pulling 5th wheels ;D Cooling was greatly improved too, even long hills to the floor for 4-5 minutes, the guage never went over 1/2 and no power robbing fan clutch until I backed off and was coasting at whatever desired speed.
It worked awesome for my old gasser, there's no standard gain that applies to all vehicles. I do believe it will be noticable, the stainless hardware will be good for many years, I can't comment on mpg though. I know for a fact I gained considerable mpg just for the fact I wasn't screaming with the throttle pegged anymore, this may also apply in your application. I've also found out dyno/bench-tested complete kits work better than custom trial-error, I would do the Banks IMO.