I have made this trip 3 times in the last year. Depends on the way you like to travel. I take exit 225 of I-10 in Florida to route 19/27. Also called the Florida Georgia Hwy. Take that to Old Town Florida Turn Left onto rt 349 3 or 4 miles and there is a brand new Good Sams CG on the right. When you leave follow 19/27 to Chiefland and turn left onto Alt 27 and follow that all the way to Ocala and I-75. This is good paved 2 lane road each way. You will encounter a few stop lights going thru the small towns, but mostly 65 mph HWY otherwise. Cuts off alot few miles and takes about the same amount of time and way way way less traffic, few trucks.