I have driven both routes many times. I usually take the one I didn't take last time.
I 84 has numerous interesting stops, if you have the time. It is an easy, four lane highway and scenic. It has one long grade, no problems if your vehicle is up to snuff. ;D
Highway 20 is mostly two lanes. Starting from the east, westbound, from Ontario to Juntura, pretty interesting high mountain desert with frequent grades and turns, some pretty tight, none too difficult. I've driven that in large vehicles, and you just need to take your time, go slow, and stay alert. Also, watch out for cattle and wildlife on the highway.
(But, then, that's the reason for going that route, isn't it?)
Juntura to Burns tapers out into ranch country, interesting the first several times you drive it.
Burns to Bend is straight. Set it on cruise control, and go take a nap. Or, at least the first time, observe the sage brush and Juniper forest. (It's Kansas, with sage brush and Juniper instead of wheat.) There are a few rest stops and Historic Sights. Don't miss them, if you have the time to stop.
By the way, watch your speed from Juntura to Bend, as the unmarked sheriff's vehicles along there do some revenue raising. :-\ It's about the only way they have, out there. (They haven't got me yet, cause I set it on cruise and take a nap.)
Bend has a lot of interesting tourist stops within 15 to 20 miles. I have spent weeks there, and not gotten it all done. Done a lot of it, several times. Depends on your interests.
Bend to Sisters is a short drive, piece o' cake. (30 minutes.) But, that's where you stop, for sure. Sisters is the best tourist trap in the country, and I never get through there in less than six or eight hours. Not sure it can be done, faster! So, go to the RV Park on the west side of town, and check in. (You can't stop a vehicle larger than a pickup truck, in town.) Leave when you have finished whatever it is that you want to do. Good idea to take a high limit credit card. :
(It's kinda like carrying life preservers on a boat.)
Sisters to Sweet Home is an interesting drive.
Mostly like a carnival ride, but you can do it. If the sign says the curve is 20mph, believe it. (That's the record that anybody has ever done it!) On downgrades, (which is most of the way,) just keep it slow. That way, you don't get a surprise and have to slow down when you can't. The scenery is majestic, but the driver doesn't get to see it. That's for passenger entertainment, only. Driver's eyes are on the road!
Sweet Home to Lebanon is a slam dunk, where the driver can watch some of the scenery, too. It's the same stuff he/she missed, for the last few hours, so it's catch up time on the fabulous scenery. (Oh, yeah, and driver can start breathing again, too!) :
Lebanon to anywhere is like Kansas, :
almost - nearly flat and wide, by comparison.
I love that drive.
Ray D. ;D