Lots of people do so. You see enclosed trailers (typically containing cars or motorcycles) and tow dollies all the time. Also boat trailers. There is nothing special about towing with a motorhome, but the usual precautions about hitch capacity and Gross Combined Weight all still apply.
We towed a boat/trailer behind a 29 foot Pace Arrow for many years. As Gary (RV Roamer) correctly said, you need to pay attention to hitch capacity and Gross Combined Weight rating (GCWR) of the motorhome.