Pay very close to weather conditions and forecast along your route. If interstates are dry, no issues. However, water may freeze as it runs across the road, or if the road is shadowed by a hill from the sun, ice and snow doesn't melt. Exercise extreme caution. Daytime towing is preferred. Black ice at night CAN NOT be seen until it is too late. If you anticipate getting into an area of snow pack on the road, I'd stop and spend the night somewhere. Proceeding is not worth the risk.
We live in middle TN. Here I've noticed two things: one is going uphill or one is going downhill. Be sure trailer brakes are correctly adjusted and working as they should. This is no time for a science experiment nor physics calculation. And be sure the tow vehicle is NOT overloaded. Likewise for the trailer. If things are unbalanced, load wise, life can get very very exciting. Pucker factor can exceed 10 !!!
Bob