It may have been mentioned but it's worth repeating so I will. A gas motorhome has a long overhang. The part of the motorhome that extends past its rear tires. In some cases that is 12 feet or more. When you make a turn, the motorhome pivots at the rear tires and the end of that long overhang swings in the opposite direction. So if there are vehicles close to your left side when making a right hand turn, the rear end of your motorhome will swing into their lane. Always observe the vehicles on the side of your motorhome that will swing into their lane as you turn. By making your turn slowly and gradually, people will see the rear of your motorhome begin to move into their lane and hopefully drive accordingly. When I need to make a sharp right turn, I move as far to the left as possible. Even into the other lane if possible. Then position the motorhome so the front is closer to the curb than the rear and proceed at an angle before making the turn. When your rear tires can clear the curb, you'll already be well into your turn and less likely to be in the other guys lane.
Another thing to keep in mind when driving on the freeway or any highway with an onramp. Many drivers don't understand the right of way laws. When driving on the freeway, you have the right of way and it's up to the vehicle entering the freeway to yield to you. Many drivers either don't understand this or are oblivious to large vehicles moving into the space they intend to occupy. If you are able calculate their approximate speed and determine their entry point of the other vehicle, you can either speed up or slow down to accommodate them. Otherwise you will need to move over, if possible.
Since you've pulled a large 5th wheel, you already know that strong winds and passing vehicles can cause your truck or tow vehilce to move somewhat. It's the trailer pushing or pulling the rear of your truck of tow vehicle that you notice. In the motorhome, it's a direct hit and you will notice it immediately. Best thing to do when a large vehilce is passing you is to pull to the right as much as possible. If there are more than 2 driving lanes, keep to the right as much as possible. It's going to be the roughest part of the road, but you'll have less issues with passing vehicles.
Driving in heavy freeway traffic can be a problem when you need to change lanes. It's been my experience that many drivers do not want to follow behind a large vehicle. Consequently they will not slow to let you move over. They might even drive faster to close a gap when you signal your turn. So it's best to know when you will need to change lanes to exit a freeway or transition to another. Not always possible and some times a missed exit will just add time to your trip. But it's better to be late by a few minutes than to risk having a collision.