Some of the above comments, well intentioned I'm sure, are out of date.
Modern technology has resulted in improvements in cost efficiency over the past few years. With our late model Dodge D3500's (not 4wd) I do average better than the common MPG figure that was normal a few years ago. Pulling our Monty nearly 20,000 miles per year over the past two years, keeping careful actual records of miles and fuel purchases, my average MPG has been15 to 18 MPG per trip. The various MPG are more dependent upon where we go (terrain), weather, and type of fuel (bio-Diesel, winter or summer blend, etc.) I do know that fuel type will make a difference of up to about 2 MPG on any trip. Speed is also a factor and I know that I get the best MPG at the most efficient speed of approximately 60-65 MPH with our RV Dodge rigs the way they are designed with the Cummins engines, manual transmissions and axle ratios. I have also noticed a factor, especially on our semis, from tire tread design and I suspect that tire design may have some effect with RV towing although I cannot say for sure.
Pulling our ranch trailers show a different result based upon the trailer for each of our Dodge trucks. The configuration, weight, load, (livestock, hay, machinery, etc.) all have effect on MPG, as does the actual road surface, terrain, weather, etc. None of these trailers are as aerodynamic as the Monty RV although the horse trailers are close and lower height, so they get the best ranch trailer MPG normally.
The days of 3 to 4 MPG with simi-trucks are also a thing of the past for most. The nine semis that I own, with 9 full time drivers, average 7 to 9 MPG, sometimes even more, again depending on trailer and load configuration, and type of fuel, etc.
In addition to ranching I have been in the trucking business since the 1960's. When fuel was cheap, (16-18 cents per gal) we used smaller, higher RPM engines in our semis. As fuel prices increased, trailers were allowed to get largers, and loads heavier, we learned that not only aerodynamics became more important, but also enginering design kept up. Among other things we learned to get the most effient MPG by including enginering advancement to increase the horsepower (torque) from the common 350 to now 650, an up, engines that run at slower RPM. Higher horsepower at slower RPM give the best efficiency. This is why today you commonly see semis with trailer wind fairings on the front, under the trailers, with smooth side panels, truck frontal, side and lower portions designed with low resistance Also all of our trucks have been equiped with APU's and auto chains for years.
I hire my own service mechanics and all of our ranch equipment and trucks equipment is serviced on a regular basis and kept in top condition in our shop. I believe that this also contributes to our efficiency results.
The above refers to diesel fuel equipment. I know the following is off subject but I believe a factor that may not be commonly known.
I live and drive in an area where we have access to both gasoline with and without ethanol. My wife and I drive a Lincoln Towncar, and a Chrysler 300C, sedans. When we fuel with pure gasoline we average about 8 to 9 percent better MPG compared to gas containing 10 percent ethanol with both cars. The fuel tank wagon delivers pure gasoline to our bulk tanks on our ranch from Wyoming and we buy pure gasoline when we regularly need to fuel at stations in Wyoming. When we drive in Colorado we fuel with ethanol gas since it is required at Colorado gas stations. So we regularly get a chance to check the results.