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If you have not purchased anything yet, the Class A may be easier for a single RVer to park. It is somewhat easier to set up. You would want a toad (vehicle TOWED behind the RV) for local travel. As a general rule, the Class A is better to travel in (down the road) and more convenient if your stops in one location are short. A 5er is more comfortable to live in if you stay in one place for longer times. 5er generally have more / bigger slides, providing more living space.
For full time comfort, do not go too small!!! A 5th Wheel (5er) will be easier to tow and to hook up than a TT (Travel Trailer). In either case, the tow vehicle is your local travel vehicle.
I STRONGLY suggest a F350 / 3500 truck if you do not have the truck yet. The SRW (single Rear Wheel) 3500 is identical to the 2500 in virtually every detail, i.e. size, inside trim, option packages. The BIG difference is a heavier suspension, which means higher payload and higher tow capacities. The GVWR and Payload are about 1500# higher on the 3500, but the price difference is less than $1000. Remember, the truck carries less than 25% of the weight of a 5er, meaning it can handle 6000# more 5er. A TT puts only about 12.5% of its' weight on the truck, so the max TT weight just went through the roof. Nobody ever complained about having too much truck.
The most important factor, regardless of what type of RV you choose is floor plan. If you do not love the floor plan, you will never like the RV.
ENJOY THE HUNT!! Come back with all your questions, and spend lots of time here reading threads and educating yourself.