I actually always drive a new to me vehicle to the low fuel warning, just to find out.
When our Sundancer starts flashing the low fuel, I can put 52 gallons in the 55 gal tank.
I've only done that once.
At ~10 mpg, that's not very far.
Our Toad gets ~43 mpg, and has a 15 Gal tank, which flashes the low fuel when it has a gallon left.
Now, in our Lincoln, Which averages 23 mpg on the highway, the low fuel lights up when it says we have 50 miles to go. At that point, I usually get about 11-12 gallons in the fill. At dead empty on the gauge, I can put 13-14 gallons in the 20 gallon tank.
Once, I pushed as far as I could before DW threatened to beat me about the head and shoulders if I did not pull into the next station, and it took a whole 16 gallons.
Those guys believe in safe margins.