Yes I do Arch. Many newer rigs do use them as they give the RV builder more design options when putting the rigs together. But the coach builders usually will put a obvious warning in the form of a sticker prominently displayed in the area where the plumbing is accessed.
In my coach there is a sticker right in the wet bay that reads "Hepvo valve must be removed prior to using any drain clearing device" . The Hepvo devices are just "duckbill" rubber pieces inside the PVC valve that allow water to flow one way into the tank and then close to prevent water or sewer gasses from coming back up the pipe.
The use of a wire, or any sharp instrument can cut, tear, or even turn the rubber flap inside out rendering it useless. However the membrane can also get "sludge" built up on the end as well, not allowing it to open all the way, or not at all. That's where the liquid cleaners help to dissolve the crud without tearing the rubber.