I have had three rear tire blowouts--two were in 3013-14 and due to defective Michelin tires. I got seven new tires from them as a result. I also recently had a rear tire blowout, cause known. It is very scary to hear that very loud explosion and have to find a quick place to pull over in heavy traffic, and it made me jumpy for a couple of months.
My biggest suggestion is to make sure everyone in wearing a seat belt. No wandering around in the rig as you drive. If someone needs a snack or to use the bathroom, they have to wait until you can pull over. That will certainly increase survive-ability in a crash. Ditto for making sure there are no loose objects that can become airborne in an accident. As the Ford test track safety manager once told me, even an apple can be fatal in a rollover. (I was working on a safety course for Ford employees.) That also applies to coffee makers, suitcases, etc. He recommended putting briefcases in the trunk or belting them in through the handles!! So, please, no magnetic knife racks in your motorhome!!!
Also, as a driver, always keep your hands on the steering wheel and your attention on the road ahead of you for chunks of metal and anything else you might run over. Recently, a big cement truck ahead of me lost the entire tread from one enormous tire. It came rolling down towards me, and I braked strongly but not in a panic. I was in the center lane and chose NOT to swerve at the last minute into another lane because I did not want to lose control. I hit it at a slower speed, and it did damage my steps, but that was better than losing control.
And finally, I drive between 60 and 65, unless it is windy or rainy, when I drive even more slowly. And I always make sure my two newest tires are on the front. The one thing I do not have is a tire pressure monitor, which I need to get, but I do get the tires checked often. I have driven 120,000 miles in past 6 years full-timing, and it is certainly sometimes scary, but you have to just take it easy and get off the road if conditions warrant. Drive what you SHOULD, not what you CAN, manufacturer ratings or not.