One of those subjects where everyone has an opinion, many differ.
Yes, there is certainly a weight factor and also a storage size issue. A full spare with hub is very heavy (?couple hundred pounds?) and can take up a full bay. There have been some creative solutions for mounting a spare underneath on brackets or on the rear hitch. Also, there is the issue of jacking up the RV and the amount of torque needed to change those big wheels.
Another question would be how much you expect a flat. I've never had one, changing my tires out when appropriate and using a TPMS to monitor the pressure. Sure, I can always hit a curb/chuckhole/spike but so far not an issue.
Personally, I think it depends on where you travel. If you are going to be somewhat near urban areas with access to cell service then a good roadside assistance plan and a credit card will get you out of most issues. If you are going to be in the wilds, driving to Alaska etc then I'd probably think about it. Then I'd also carry the appropriate jacks and breaker bars to ensure I could safely change the tire.
Some carry just the spare tire figuring the issue would be more getting a replacement tire and that as long as they have one almost any truck/tire shop can mount it. Still takes up the same space but weighs less of course.
So based on that, I choose not to try to carry a spare and depend on my Coachnet to help me out.
Anyways, just my opinion.