You'll love it and you're coming in to the best time of year to be on the west coast. You won't find anything on 101 to cause you problems... top to bottom. 101 runs parallel to US1 or PCH (Pacific Coast Hwy) which is one of the most scenic roads anywhere. BUT.... much of that is best seen from your toad. Especially headed south you could find yourself in trouble with your co-pilot who would be hanging out over the cliffs much of the trip.
Oregon State Parks are the best we've found anywhere and Cape Blanco State Park there is one of our favorite all time spots. Secluded sites in the trees but a 100 yard stroll and you can watch whales from the cliffs or hike a beautiful trail to the lighthouse.
If you have any handling issues with your coach, you'll be passing through Grants Pass, Oregon and Henderson's Line Up there is top notch.
Fort Bragg area in NorCal is very nice. Unless SF is on your bucket list for this trip the advice to take I5 around it is probably a good idea. There's no easy way to get through my home town in a car and a big rig.... well.
The central coast, Santa Barbara, Pismo Beach, Solvang, etc are all within easy reach of 101 and are spectacular. Flying Flags RV Resort in Buelton just off of 101 is a very nice park to base and visit Santa Barbara and Solvang. Another option in that area that we love is Lake Cachuma County park.
If you are around LA and need a place to overnight, we always use East Shore RV Park in San Dimas. It isn't the cheapest place in the area but very nice and pretty easy to get to. The big Pamona RV show is coming up and only a few blocks from there too. If you do stay there and feel like splurging on a really nice site, ask for one of their "executive" sights overlooking the lake. Very nice for being in LA basin.
Unless you wanted to head to San Diego, I10 would be the way you would want to head east. If you're not going to visit LA, you can cut over from I5 across the 210 to I10 through Pasedena. East Shore would be on your way using that route. If you do go to San Diego, then you'd probably want to use I8 to head east at least to Yuma/Gila Bend. In the Phoenix area (where our grandbabies live) we stay at Destiny RV Resort in Goodyear, Az. Nothing spectacular but an easy stop with long pull throughs.
As you head east you might consider Kartchner Caverns State Park just south of 10 on the road to Tombstone. As you head across Texas, we have found we like to overnight at the Fort Stockton RV Park http://www.travelingusa.com/business/fortstocktonkoa/index.html?from_cat=Places%20to%20Stay because the pull throughs are easy to access and they have their own home cooking cafe on site.
As you near San Antonio about 60 miles east is Buckhorn Lake Resort... very nice. There is a park in downtown San Antonio we stayed at as well with easy public transit access. If you plan to see New Orleans consider the French Quarter RV Resort. Pricey but located within walking distance of the French Qtr with great security.
From there you're probably more knowledgeable about the areas than I but we just made that big loop this past winter and are now in Minnesota about to head back to Arizona and then California in a few weeks.
Safe Travels...
Rick