In spite of the hype about "half ton" you might not be able to tow even the smallest one of these safely. Being a fifth wheel there will be 20%-25% of the total trailer weight on the pin in the truck bed. The lightest of these, the 22MLS, has a shipping weight (dry weight) of 5,731 lbs, with a 1469 lb "carrying capacity." That's a 7200 lb max weight (which needs to be the point of comparison), and with 20% of that being 1440 lbs, that's probably at or over the max payload on your F-150. Add people, baggage, whatever you carry in the truck and your truck is likely overloaded. Chances are good that your rear axle, in and of itself, is also overloaded.
So even if you manage to squeak by just under the wire, I still suspect you wouldn't like the performance or the handling.
Driving the pickup is, of course, pretty easy, mostly like a car, and towing a trailer isn't difficult, but backing and cornering takes practice (a large, empty parking lot would be a good place for practice), and you do need to learn about height and width clearance, as well as where the trailer tracks behind the pickup so that you can make it around corners without running over the curb or hitting objects with the side of the trailer.
If you want that trailer (even the smallest of them), you'll really want an F-250 or larger. If you stay with the F-150 you really should forget the 5th wheel and go to a travel trailer (some call them bumper pull, but they're not, really), watching the weight carefully. Even there, the 10-15% of trailer eight (at least 12% recommended) will add to the payload on the truck.
So load the pickup with everyone who'll be traveling with you, full fuel and all the tools, baggage and whatever else, and go to a scale (the CAT scales at truck stops are one good way) and get weighed AT LEAST by axle, and wheel by wheel if possible.
Then you'll know how much capacity the truck has (compare with the yellow sticker on your doorpost) and can make informed choices about trailers -- use GVWR (max allowable weight) -- and ensure that you don't overload the truck.
Also, don't trust sales people to guide you in this, since their main task is to sell the trailer, not to give accurate advice, and they often don't know any better anyway.
P.S. You'll also need to add trailer hitch (or fifth wheel hitch) weight (perhaps 100-200 lbs) to the load the truck is carrying before putting a trailer on it.