What do you consider best? I am from the Boston area.
Going to Daytona…
For me, best is to avoid NYC, Philly, DC etc so I go Mass pike to I84 all the way to Scranton, then I81 to I77 just after Christianburg and south …
for you, just after Fancy Gap in I77, take I74 down to I95 and you are just north of Myrtle Beach.
An alternative is at Staunton VA on I81, take I64 to Richmond and I95 south.
Depends on your tolerance to huge traffic jams, 4 & 5 lane highways etc.
Oh, one time I went through MD on I95 hauling a trailer using ezpass, I got a $50 ticket from MD for not paying extra for the trailer. I don’t go to MD anymore except for the short stretch on I81.